Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

PDB ID: 2C7V
Gene source organism: TRYPANOSOMA BRUCEI BRUCEI
Expression organism: ESCHERICHIA COLI Deposition date: 2005-11-29
Classification: OXIDOREDUCTASE
Keywords: PTERIDINE REDUCTASE, TRYPANOSOMATIDS, DRUG RESISTANCE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE, METHOTREXATE RESISTANCE, OXIDOREDUCTASE
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.2
R-value: 0.153
Metal site idBound amino acidsBound ligands IDs
2C7V-NI-1 H2 HIS A.179 HIS C.179
2C7V-NI-2 H2 HIS B.179 HIS D.179