Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity

PDB ID: 2F53
Gene source organism: Homo sapiens
Expression organism: Escherichia coli BL21 Deposition date: 2005-11-25
Classification: IMMUNE SYSTEM
Keywords: T-cell Receptor, CDR2, Phage Display, Mutant, High Affinity, NY-ESO-1, IMMUNE SYSTEM
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.0
R-value: 0.166
Metal site idBound amino acidsBound ligands IDs
2F53-NA-1 Q1T1 GLN A.155 HOH C.18 THR C.7