Crystal Structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

PDB ID: 2VES
Gene source organism: Pseudomonas aeruginosa
Expression organism: Escherichia coli Deposition date: 2007-10-26
Classification: HYDROLASE
Keywords: LPXC, HYDROLASE, BB-78485, ANTIBIOTICS, DEACETYLASE, LIPID SYNTHESIS, METALLOPROTEASE, HYDROXAMIC ACID, GRAM-NEGATIVE BACTERIA, LIPOPOLYSACCHARIDE, LIPID A BIOSYNTHESIS
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 1.9
R-value: 0.177
Metal site idBound amino acidsBound ligands IDs
2VES-ZN-1 D2E1 ASP A.159 ASP A.161 GLU B.219
2VES-ZN-2 E1Q1S1 GLN A.203 GLU C.134 HOH C.2406 HOH C.2407 HOH C.2408 SER C.136