crystal structure of human insulin degrading enzyme in complex with iodinated insulin

PDB ID: 2WC0
Gene source organism: HOMO SAPIENS
Expression organism: ESCHERICHIA COLI Deposition date: 2009-03-06
Classification: HYDROLASE/HORMONE
Keywords: HYDROLASE/HORMONE, ZINC, DIOXANE, INSULIN, HORMONE, PROTEASE, SECRETED, HUMAN INSULIN-DEGRADING ENZYME, DISULFIDE BOND, METALLOPROTEASE, GLUCOSE METABOLISM, CARBOHYDRATE METABOLISM, HYDROLASE, CYTOPLASM, POLYMORPHISM, METAL-BINDING, CLEAVAGE ON PAIR OF BASIC RESIDUES, HYDROLASE-HORMONE complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.8
R-value: 0.17
Metal site idBound amino acidsBound ligands IDs
2WC0-ZN-1 F1H2 HIS A.108 HIS A.112 PHE D.1