Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)

PDB ID: 3INM
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2009-08-12
Classification: OXIDOREDUCTASE
Keywords: ROSSMANN FOLD, NADP, KETOGLUTARATE, QUATERNARY COMPLEX, OXIDOREDUCTASE, Glyoxylate bypass, Magnesium, Manganese, Metal-binding, Peroxisome, Tricarboxylic acid cycle
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.1
R-value: 0.22
Metal site idBound amino acidsBound ligands IDs
3INM-CA-1 D3 AKG A.511 ASP A.275 ASP A.279 ASP B.252 HOH A.426 HOH A.427
3INM-CA-2 D3 AKG B.511 ASP A.252 ASP B.275 ASP B.279 HOH B.427 HOH B.428