Crystal Structure of Human Flap Endonuclease FEN1 (WT) in complex with product 5'-flap DNA, SM3+, and K+

PDB ID: 3Q8K
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2011-01-06
Classification: HYDROLASE/DNA
Keywords: helix-3 turn-helix, hydrophobic wedge, 3' flap binding site, hydrolase-DNA complex, DNA repair, replication, flap endonuclease, FEN, FEN1, DNA, nuclease, 5' flap, ss-dsDNA junction, helix-2 turn-helix, H2TH, H3TH, divalent cation, helical gateway, cap, acid block, two metal mechanism, unpaired, 5' nuclease, human, long patch base excision repair
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.2
R-value: 0.1679
Metal site idBound amino acidsBound ligands IDs
3Q8K-SM-1 D2E1T1 ASP A.179 ASP A.181 DT E.2 GLU A.160 HOH A.555 OH A.347