Human DNA polymerase eta inserting dCMPNPP opposite the 3'G of cisplatin crosslinked Gs (Pt-GG1).

PDB ID: 4DL4
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-02-05
Classification: TRANSFERASE/DNA/INHIBITOR
Keywords: cisplatin, chemoresistence, translesion synthesis, human DNA polymerse eta, kinetics, molecular splint, inhibition, DNA distorsion, second TLS polymerase, nucleotidyl transfer reaction, PCNA, TRANSFERASE-DNA-INHIBITOR complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.0
R-value: 0.1943
Metal site idBound amino acidsBound ligands IDs
4DL4-MG-1 D2E1G1 0KX P.10 ASP A.115 ASP A.13 DG P.9 GLU A.116 HOH A.601