Human DNA polymerase eta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2).

PDB ID: 4DL5
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-02-05
Classification: TRANSFERASE/DNA/INHIBITOR
Keywords: cisplatin, chemoresistence, translesion synthesis, human DNA polymerse eta, kinetics, molecular splint, inhibition, DNA distorsion, second TLS polymerase, nucleotidyl transfer reaction, PCNA, TRANSFERASE-DNA-INHIBITOR complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.92
R-value: 0.245
Metal site idBound amino acidsBound ligands IDs
4DL5-MG-1 C1D2E1 0KX A.503 ASP A.115 ASP A.13 DC P.9 GLU A.116