Human DNA polymerase eta extending primer immediately after cisplatin crosslink (Pt-GG3).

PDB ID: 4DL6
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-02-05
Classification: TRANSFERASE/DNA/INHIBITOR
Keywords: cisplatin, chemoresistence, translesion synthesis, human DNA polymerse eta, kinetics, molecular splint, inhibition, DNA distorsion, second TLS polymerase, nucleotidyl transfer reaction, PCNA, TRANSFERASE-DNA-INHIBITOR complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.5
R-value: 0.202
Metal site idBound amino acidsBound ligands IDs
4DL6-MG-1 C1D2E1 ASP A.115 ASP A.13 DC P.9 GLU A.116 HOH A.631 XG4 A.503