Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

PDB ID: 4HZT
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-11-15
Classification: hydrolase/hydrolase inhibitor
Keywords: Aspartic protease, Hydrolysis, hydrolase-hydrolase inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 2
Resolution: 1.8
R-value: 0.19758
Metal site idBound amino acidsBound ligands IDs
4HZT-ZN-1 H2 HIS A.110 HIS A.150
4HZT-ZN-2 H2 HIS A.110 HIS A.150