Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors

PDB ID: 4I0F
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-11-16
Classification: hydrolase/hydrolase inhibitor
Keywords: BACE, Aspartic protease, hydrolysis, hydrolase-hydrolase inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 2
Resolution: 1.8
R-value: 0.20822
Metal site idBound amino acidsBound ligands IDs
4I0F-ZN-1 H2 HIS A.110 HIS A.150