SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors

PDB ID: 4I0J
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-11-16
Classification: hydrolase/hydrolase inhibitor
Keywords: BACE Asp protease, hydrolysis, hydrolase-hydrolase inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 2
Resolution: 1.8
R-value: 0.22572
Metal site idBound amino acidsBound ligands IDs
4I0J-ZN-1 E3 GLU A.138 GLU A.165 HOH A.709
4I0J-ZN-2 E3 GLU A.138 GLU A.165 HOH A.709