Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.

PDB ID: 4I11
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-11-19
Classification: transferase/transferase inhibitor
Keywords: BACE-1, transferase-transferase inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 2
Resolution: 1.89
R-value: 0.21537
Metal site idBound amino acidsBound ligands IDs
4I11-ZN-1 H2 HIS A.110 HIS A.150