Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors

PDB ID: 4I12
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2012-11-19
Classification: hydrolase/hydrolase inhibitor
Keywords: Aspartic protease, hydrolase-hydrolase inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 2
Resolution: 1.78
R-value: 0.228
Metal site idBound amino acidsBound ligands IDs
4I12-ZN-1 H2 HIS A.110 HIS A.150