yCP beta5-A49T-A50V-double mutant in complex with carfilzomib

PDB ID: 4QWK
Gene source organism: Saccharomyces cerevisiae
Expression organism: SACCHAROMYCES CEREVISIAE Deposition date: 2014-07-16
Classification: HYDROLASE/HYDROLASE INHIBITOR
Keywords: Cancer, Proteasome, Bortezomib, Drug Resistance, Binding Analysis, HYDROLASE-HYDROLASE INHIBITOR complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.8
R-value: 0.18153
Metal site idBound amino acidsBound ligands IDs
4QWK-MG-1 A1D2S1 ALA K.165 ASP K.168 ASP W.204 SER K.171
4QWK-MG-2 D2I1S1 ASP L.222 ASP V.166 ILE V.163 SER V.169
4QWK-MG-3 A1D2S1 ALA Y.165 ASP I.204 ASP Y.168 SER Y.171