yCP beta5-A50V mutant in complex with carfilzomib

PDB ID: 4QWL
Gene source organism: Saccharomyces cerevisiae
Expression organism: SACCHAROMYCES CEREVISIAE Deposition date: 2014-07-16
Classification: HYDROLASE/HYDROLASE INHIBITOR
Keywords: Cancer, Proteasome, Bortezomib, Drug Resistance, Binding Analysis, HYDROLASE-HYDROLASE INHIBITOR complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.6
R-value: 0.19258
Metal site idBound amino acidsBound ligands IDs
4QWL-MG-1 A1D2S1 ALA K.165 ASP K.168 ASP W.204 SER K.171
4QWL-MG-2 D1N1Q1 ASN N.92 ASP N.51 GLN H.91 HOH H.418
4QWL-MG-3 D2I1S1 ASP L.222 ASP V.166 HOH V.404 ILE V.163 SER V.169
4QWL-MG-4 A1D2S1 ALA Y.165 ASP I.204 ASP Y.168 HOH Y.414 SER Y.171