JAK2 kinase (JH1 domain) mutant P1057A in complex with TG101209

PDB ID: 5HEZ
Gene source organism: Homo sapiens
Expression organism: Spodoptera frugiperda Deposition date: 2016-01-06
Classification: TRANSFERASE/TRANSFERASE INHIBITOR
Keywords: protein kinase, inhibitor, mutation, TYK2, surrogate, P1104A, TRANSFERASE-TRANSFERASE INHIBITOR complex
Technique: X-RAY DIFFRACTION
Assembly: 5
Resolution: 2.66
R-value: 0.2169
Metal site idBound amino acidsBound ligands IDs
5HEZ-ZN-1 H4 HIS A.886 HIS A.891 HIS D.886 HIS D.891
5HEZ-ZN-2 H4 HIS A.886 HIS A.891 HIS D.886 HIS D.891
5HEZ-ZN-3 H4 HIS B.886 HIS B.891 HIS C.886 HIS C.891
5HEZ-ZN-4 H4 HIS B.886 HIS B.891 HIS C.886 HIS C.891