Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid

PDB ID: 5I95
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2016-02-19
Classification: OXIDOREDUCTASE
Keywords: IDH, ICD-M, IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase, aKG, alphaKG, oxo-glutarate., OXIDOREDUCTASE
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 1.54
R-value: 0.1422
Metal site idBound amino acidsBound ligands IDs
5I95-CA-1 D2 AKG A.508 ASP A.291 ASP A.314 HOH A.619 HOH A.658
5I95-CA-2 D2 AKG A.508 ASP A.291 ASP A.314 HOH A.619 HOH A.658