Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd1

PDB ID: 6BKX
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2017-11-09
Classification: OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Keywords: dehydrogenase, inhibitor, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 1.65
R-value: 0.165
Metal site idBound amino acidsBound ligands IDs
6BKX-CA-1 D3 ASP C.252 ASP C.275 ASP C.279 HOH C.651 HOH C.726 ICT C.502
6BKX-CA-2 D3 ASP C.252 ASP C.275 ASP C.279 HOH C.651 HOH C.726 ICT C.502