Novel Modes of Inhibition of Wild-Type IDH1:Direct Covalent Modification of His315 with Cmpd11

PDB ID: 6BL0
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2017-11-09
Classification: OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Keywords: dehydrogenase, inhibitor, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 2
Resolution: 2.165
R-value: 0.196
Metal site idBound amino acidsBound ligands IDs
6BL0-MG-1 D2 ASP C.252 ASP C.275 HOH C.606 HOH C.632 ICT C.501
6BL0-MG-2 D2 ASP C.252 ASP C.275 HOH C.606 HOH C.632 ICT C.501