Novel Modes of Inhibition of Wild-Type IDH1: Direct Covalent Modification of His315 with Cmpd15

PDB ID: 6BL2
Gene source organism: Homo sapiens
Expression organism: Escherichia coli Deposition date: 2017-11-09
Classification: oxidoreductase/oxidoreductase inhibitor
Keywords: dehydrogenase, inhibitor, OXIDOREDUCTASE, oxidoreductase-oxidoreductase inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 1.92
R-value: 0.18
Metal site idBound amino acidsBound ligands IDs
6BL2-CA-1 D2 ASP A.275 ASP C.252 HOH A.603 HOH A.744 ICT A.502
6BL2-CA-2 D2 ASP A.252 ASP C.275 HOH C.615 HOH C.762 ICT A.505