The Alkyne Moiety as a Latent Electrophile in Irreversible Covalent Small Molecule Inhibitors of Cathepsin K

PDB ID: 6QBS
Gene source organism: Homo sapiens
Expression organism: Komagataella phaffii GS115 Deposition date: 2018-12-21
Classification: HYDROLASE
Keywords: Covalent Inhibitor, Cathepsin K, hydrolase
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 1.7
R-value: 0.2043
Metal site idBound amino acidsBound ligands IDs
6QBS-CA-1 E2N2Q2 ASN A.70 ASN B.285 GLN A.73 GLN B.288 GLU A.59 GLU B.274