Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with NADPH and AG-881 (Vorasidenib) Inhibitor.

PDB ID: 6VFZ
Gene source organism: Homo sapiens
Expression organism: Spodoptera frugiperda Deposition date: 2020-01-07
Classification: OXIDOREDUCTASE/OXIDOREDUCTASE inhibitor
Keywords: IDH, ICD-M, IDP, NADP(+)-SPECIFIC ICDH, OXALOSUCCINATE DECARBOXYLASE, OXIDOREDUCTASE-OXIDOREDUCTASE inhibitor complex
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 1.99
R-value: 0.1774
Metal site idBound amino acidsBound ligands IDs
6VFZ-CA-1 D3 ASP A.314 ASP A.318 ASP B.291 HOH A.710 HOH A.739 HOH A.884
6VFZ-CA-2 D3 ASP A.291 ASP B.314 ASP B.318 HOH B.696 HOH B.772 HOH B.778