Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution.

PDB ID: 7PIU
Gene source organism: Homo sapiens
Expression organism: Spodoptera aff. frugiperda 1 BOLD-2017 Deposition date: 2021-08-23
Classification: SIGNALING PROTEIN
Keywords: GPCR, MELANOCORTIN-4 RECEPTOR, MELANOCORTIN RECEPTORS, SETMELANOTIDE, NDP-ALPHA-MSH, ALPHA-MSH, ANTAGONISM, AGONISM, APPETITE REGULATION, ANTI-OBESITY TREATMENT, SIGNALING PROTEIN
Technique: ELECTRON MICROSCOPY
Assembly: 1
Resolution: None
R-value: None
Metal site idBound amino acidsBound ligands IDs
7PIU-CA-1 D1X1 ASP R.126 DPN P.5