Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and Ca2+/2-Oxoglutarate

PDB ID: 7PJM
Gene source organism: Homo sapiens
Expression organism: Escherichia coli BL21(DE3) Deposition date: 2021-08-24
Classification: OXIDOREDUCTASE
Keywords: OXIDOREDUCTASE
Technique: X-RAY DIFFRACTION
Assembly: 1
Resolution: 2.1
R-value: 0.1805
Metal site idBound amino acidsBound ligands IDs
7PJM-CA-1 D3 AKG A.501 ASP A.275 ASP A.279 ASP B.252 HOH A.655 HOH A.694
7PJM-CA-2 D3 AKG B.502 ASP A.252 ASP B.275 ASP B.279 HOH B.611 HOH B.637