Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase (IDH2) R140Q Mutant Homodimer in Complex with AG-221 (Enasidenib) Inhibitor.

PDB ID: 5I96
Metal site ID: 5I96-CA-2
Bound amino acids or nucleotide residues: D3
Group identifier: D1K1V1
Is homomeric: True
Amino acid or nucleotide residue IDs: ASP A.291 ASP B.314 ASP B.318
All ligands IDs: ASP A.291 ASP B.314 ASP B.318 HOH B.705 HOH B.720 HOH B.782
Number of coordinating amino acids or nucleotide residues: 3
Number of coordinating ligands: 6
Number of coordinating chains: 2
Number of coordinating chains: 2
Representative metal site in the group: 5I96-CA-2
Similar binding_sites:
Metal site idBound amino acidsBound ligands IDs
6VFZ-CA-1D3 ASP A.314 ASP A.318 ASP B.291 HOH A.710 HOH A.739 HOH A.884
6VFZ-CA-2D3 ASP A.291 ASP B.314 ASP B.318 HOH B.696 HOH B.772 HOH B.778