Crystal Structure of Ivosidenib-resistant IDH1 variant R132C S280F in complex with NADPH and Ca2+/2-Oxoglutarate

PDB ID: 7PJM
Metal site ID: 7PJM-CA-1
Bound amino acids or nucleotide residues: D3
Group identifier: K1R1V1
Is homomeric: True
Amino acid or nucleotide residue IDs: ASP A.275 ASP A.279 ASP B.252
All ligands IDs: AKG A.501 ASP A.275 ASP A.279 ASP B.252 HOH A.655 HOH A.694
Number of coordinating amino acids or nucleotide residues: 3
Number of coordinating ligands: 6
Number of coordinating chains: 2
Number of coordinating chains: 2
Representative metal site in the group: 3INM-CA-1
Similar binding_sites:
Metal site idBound amino acidsBound ligands IDs
6BKY-MG-2D3 ASP C.275 ASP C.279 ASP D.252
7PJM-CA-1D3 AKG A.501 ASP A.275 ASP A.279 ASP B.252 HOH A.655 HOH A.694
7PJM-CA-2D3 AKG B.502 ASP A.252 ASP B.275 ASP B.279 HOH B.611 HOH B.637