CtIDH bound to NADP. The complex structures of Isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila, support a new active site locking mechanism

PDB ID: 4AOU
Metal site ID: 4AOU-MG-2
Bound amino acids or nucleotide residues: D2
Group identifier: A1D3S1
Is homomeric: True
Amino acid or nucleotide residue IDs: ASP A.250 ASP A.273
All ligands IDs: ASP A.250 ASP A.273 HOH A.2029 ICT A.1403
Number of coordinating amino acids or nucleotide residues: 2
Number of coordinating ligands: 4
Number of coordinating chains: 2
Number of coordinating chains: 2
Representative metal site in the group: 4L03-CA-1
Similar binding_sites:
Metal site idBound amino acidsBound ligands IDs
1T0L-CA-1D2 ASP A.275 ASP B.252 HOH A.1763 ICT A.1616
1T0L-CA-2D2 ASP A.252 ASP B.275 HOH B.1897 ICT B.1617
2QFX-CA-1D2 AKG A.1102 ASP A.277 ASP B.254
2QFX-CA-2D3 AKG B.1202 ASP A.254 ASP B.277 ASP B.281
2UXR-MG-2D2 ASP A.249 ASP B.272 ICT B.1397
4AOU-MG-1D2 ASP A.250 ASP A.273 HOH A.2029 ICT A.1403
4AOU-MG-2D2 ASP A.250 ASP A.273 HOH A.2029 ICT A.1403
4KZO-CA-1D3 AKG A.503 ASP A.275 ASP A.279 ASP B.252 HOH A.601 HOH A.602
4KZO-CA-2D3 AKG B.503 ASP A.252 ASP B.275 ASP B.279 HOH B.601 HOH B.602
4L03-CA-2D3 AKG C.503 ASP C.252 ASP C.275 ASP C.279 HOH C.601 HOH C.602
4L04-CA-1D3 AKG A.501 ASP A.275 ASP A.279 ASP B.252
4L06-CA-1D3 AKG C.503 ASP C.275 ASP C.279 ASP D.252 HOH C.610
4L06-CA-2D3 AKG D.503 ASP C.252 ASP D.275 ASP D.279
6AJC-CA-1D3 ASP A.274 ASP A.278 ASP B.251 ICT A.503
6AJC-CA-2D3 ASP A.251 ASP B.274 ASP B.278 HOH B.602 ICT B.503