4I12 |
Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors |
hydrolase/hydrolase inhibitor |
Aspartic protease, hydrolase-hydrolase inhibitor complex |
11/19/2012 |
1.78 |
0.228 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
5U9T |
The Tris-thiolate Zn(II)S3Cl Binding Site Engineered by D-Cysteine Ligands in de Novo Three-stranded Coiled Coil Environment |
DE NOVO PROTEIN |
De Novo Three-stranded Coiled Coil, De Novo Design, D-amino Acids in Protein Design, D-Cysteine, Tris-thiolate Zn(II)S3Cl complex, DE NOVO PROTEIN |
12/18/2016 |
1.92 |
0.197 |
synthetic construct |
— |
X-RAY DIFFRACTION |
1 |
5W6P |
Crystal structure of Bacteriophage CBA120 tailspike protein 2 enzymatically active domain (TSP2dN, orf211) |
viral protein, hydrolase |
CBA120, tailspikes, hydrolase, VIRAL PROTEIN |
06/16/2017 |
2.33 |
0.154 |
Escherichia phage Cba120 |
Escherichia coli B |
X-RAY DIFFRACTION |
2 |
4WZ9 |
APN1 from Anopheles gambiae |
HYDROLASE |
aminopeptidase, metalloprotease, HYDROLASE |
11/19/2014 |
2.65 |
0.20001 |
Anopheles gambiae |
Drosophila |
X-RAY DIFFRACTION |
1 |
4U9E |
Crystal structure of the Zn-directed tetramer of the engineered cyt cb562 variant, A104/57G AB3 |
ELECTRON TRANSPORT |
designed enzyme, Zn-coordinating protein, tetramer assembly, ELECTRON TRANSPORT |
08/06/2014 |
2.8 |
0.237 |
Escherichia coli |
ESCHERICHIA COLI |
X-RAY DIFFRACTION |
1 |
7BD7 |
X-ray structure of Arsenoplatin-1-encapsulated horse spleen ferritin |
TRANSPORT PROTEIN |
ferritin, drug delivery, metallodrug, arsenoplatin, anticancer, TRANSPORT PROTEIN |
12/21/2020 |
1.5 |
0.1663 |
Equus caballus |
— |
X-RAY DIFFRACTION |
1 |
2W0F |
Potassium Channel KcsA-Fab Complex with Tetraoctylammonium |
IMMUNE SYSTEM/METAL TRANSPORT |
IMMUNE SYSTEM METAL TRANSPORT COMPLEX, QUATERNARY AMMONIUM, PROTEIN-ANTIBODY FAB COMPLEX, IONIC CHANNEL, ION TRANSPORT, POTASSIUM CHANNEL, IMMUNE SYSTEM-METAL TRANSPORT complex |
08/14/2008 |
2.4 |
0.2 |
MUS MUSCULUS |
MUS MUSCULUS |
X-RAY DIFFRACTION |
1 |
3PQI |
Crystal structure of the bacteriophage phi92 membrane-piercing protein gp138 |
VIRAL PROTEIN |
Beta-Helix, OB-Fold, Phage Baseplate, Iron-Binding, Cell membrane piercing, VIRAL PROTEIN |
11/26/2010 |
2.64 |
0.2107 |
Bacteriophage phi92 |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
2DF7 |
Crystal structure of infectious bursal disease virus VP2 subviral particle |
VIRUS LIKE PARTICLE |
icosahedral capsid, immunogen, epitope, surface loop, VIRUS LIKE PARTICLE |
02/27/2006 |
2.6 |
0.165 |
Infectious bursal disease virus |
Trichoplusia ni |
X-RAY DIFFRACTION |
1 |
1V3W |
Structure of Ferripyochelin binding protein from Pyrococcus horikoshii OT3 |
TRANSFERASE |
BETA-HELIX, Carbonic anhydrase, STRUCTURAL GENOMICS, RIKEN Structural Genomics/Proteomics Initiative, RSGI, TRANSFERASE |
11/07/2003 |
1.5 |
0.185 |
Pyrococcus horikoshii |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
1XZO |
Identification of a disulfide switch in BsSco, a member of the Sco family of cytochrome c oxidase assembly proteins |
METAL BINDING PROTEIN |
thioredoxin-like fold, Structural Genomics, Montreal-Kingston Bacterial Structural Genomics Initiative, BSGI, METAL BINDING PROTEIN |
11/12/2004 |
1.7 |
0.23824 |
Bacillus subtilis |
Escherichia coli |
X-RAY DIFFRACTION |
3 |
4P6V |
Crystal structure of the Na+-translocating NADH: ubiquinone oxidoreductase from Vibrio cholerae |
OXIDOREDUCTASE |
Respiratory Complex, NADH:ubiquinone oxidoreductase, Sodium translocation, FAD, covalent FMN, Riboflavin, OXIDOREDUCTASE |
03/25/2014 |
3.5 |
0.2458 |
Vibrio cholerae serotype O1 |
Vibrio cholerae |
X-RAY DIFFRACTION |
1 |
6OT8 |
Bimetallic hexameric cage design 4 (BMC4) from cytochrome cb562 |
METAL BINDING PROTEIN |
Supramolecular assembly, protein cage, bimetallic, metal binding, hydroxamic acid, METAL BINDING PROTEIN |
05/02/2019 |
1.5 |
0.19 |
Escherichia coli |
Escherichia coli BL21(DE3) |
X-RAY DIFFRACTION |
1 |
6VXT |
Activated Nitrogenase MoFe-protein from Azotobacter vinelandii |
OXIDOREDUCTASE |
Azotobacter vinelandii, MoFe-protein, Fe-protein, FeMo-cofactor, P-cluster, OXIDOREDUCTASE |
02/24/2020 |
1.73 |
0.1724 |
Azotobacter vinelandii |
— |
X-RAY DIFFRACTION |
1 |
2GK2 |
Crystal structure of the N terminal domain of human CEACAM1 |
CELL ADHESION |
immunoglobulin domain, adhesion protein, CELL ADHESION |
03/31/2006 |
2.2 |
0.21 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
4 |
4JRZ |
Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis |
LYASE |
Leukotriene C4 synthase, product analogs, lipid biosynthesis, LYASE |
03/22/2013 |
2.4 |
0.233 |
Homo sapiens |
Pichia Pastoris |
X-RAY DIFFRACTION |
1 |
2UUI |
Crystal structure of Human Leukotriene C4 Synthase |
LYASE |
LEUKOTRIENE SIGNALLING, LEUKOTRIENE BIOSYNTHESIS, MEMBRANE, EICOSANOID, TRANSMEMBRANE, MEMBRANE PROTEIN, APO, LYASE, MAPEG, HUMAN, LTC4S, ENZYME, TRIMER |
03/02/2007 |
1.7 |
0.196 |
HOMO SAPIENS |
PICHIA PASTORIS |
X-RAY DIFFRACTION |
1 |
5YTL |
Crystal structure of Geobacillus thermodenitrificans copper-containing nitrite reductase determined with an anaerobically manipulated crystal |
OXIDOREDUCTASE |
copper, nitrite reductase, OXIDOREDUCTASE |
11/19/2017 |
1.4 |
0.1132 |
Geobacillus thermodenitrificans |
Escherichia coli BL21(DE3) |
X-RAY DIFFRACTION |
1 |
8EA4 |
V-K CAST Transpososome from Scytonema hofmanni, minor configuration |
DNA BINDING PROTEIN/RNA/DNA |
DNA BINDING PROTEIN, DNA BINDING PROTEIN-RNA-DNA complex |
08/27/2022 |
— |
— |
Scytonema hofmannii |
Escherichia coli |
ELECTRON MICROSCOPY |
1 |
8EA3 |
V-K CAST Transpososome from Scytonema hofmanni, major configuration |
DNA BINDING PROTEIN/DNA/RNA |
DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA-RNA complex |
08/27/2022 |
— |
— |
Scytonema hofmannii |
Escherichia coli |
ELECTRON MICROSCOPY |
1 |