| 4HL2 |
New Delhi Metallo-beta-Lactamase-1 1.05 A structure Complexed with Hydrolyzed Ampicillin |
Hydrolase/Antibiotic |
Structural Genomics, PSI-Biology, Midwest Center for Structural Genomics, MCSG, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors, MTBI, alpha-beta-beta-alpha sandwich, hydrolase, Hydrolase-Antibiotic complex |
10/15/2012 |
1.05 |
0.133 |
Klebsiella pneumoniae |
Escherichia coli |
X-RAY DIFFRACTION |
3 |
| 4I0Z |
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates |
hydrolase/hydrolase inhibitor |
Aspartic protease, hydrolase-hydrolase inhibitor complex |
11/19/2012 |
1.8 |
0.20644 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
| 4I11 |
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. |
transferase/transferase inhibitor |
BACE-1, transferase-transferase inhibitor complex |
11/19/2012 |
1.89 |
0.21537 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
| 4I0D |
Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors |
hydrolase/hydrolase inhibitor |
BACE, Aspartic protease, hydrolysis, hydrolase-hydrolase inhibitor complex |
11/16/2012 |
1.9 |
0.20302 |
Homo sapiens |
— |
X-RAY DIFFRACTION |
2 |
| 4I0F |
Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors |
hydrolase/hydrolase inhibitor |
BACE, Aspartic protease, hydrolysis, hydrolase-hydrolase inhibitor complex |
11/16/2012 |
1.8 |
0.20822 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
| 4I0J |
SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors |
hydrolase/hydrolase inhibitor |
BACE Asp protease, hydrolysis, hydrolase-hydrolase inhibitor complex |
11/16/2012 |
1.8 |
0.22572 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
| 4I1C |
Design and synthesis of thiophene dihydroisoquinolins as novel BACE-1 inhibitors |
hydrolase/hydrolase inhibitor |
Aspartic protease, hydrolase-hydrolase inhibitor complex |
11/20/2012 |
2.0 |
0.20731 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
| 4HTM |
Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2 |
PROTEIN BINDING |
alpha-helix, CREB binding, CREB, PROTEIN BINDING |
11/01/2012 |
1.8 |
0.24791 |
Homo sapiens |
— |
X-RAY DIFFRACTION |
2 |
| 4HZT |
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates |
hydrolase/hydrolase inhibitor |
Aspartic protease, Hydrolysis, hydrolase-hydrolase inhibitor complex |
11/15/2012 |
1.8 |
0.19758 |
Homo sapiens |
Escherichia coli |
X-RAY DIFFRACTION |
2 |
| 4EX0 |
Human Insulin |
HORMONE |
HORMONE |
04/29/2012 |
1.86 |
0.1672 |
Homo sapiens |
— |
X-RAY DIFFRACTION |
1 |
| 4EYB |
Crystal structure of NDM-1 bound to hydrolyzed oxacillin |
Hydrolase/antibiotic |
Metallo Beta Lactamase, antibiotic, Hydrolase-antibiotic complex |
05/01/2012 |
1.16 |
0.135 |
Klebsiella pneumoniae |
Escherichia coli |
X-RAY DIFFRACTION |
3 |
| 4EYF |
Crystal structure of NDM-1 bound to hydrolyzed benzylpenicillin |
Hydrolase/antibiotic |
Metallo Beta Lactamase, antibiotic, Hydrolase-antibiotic complex |
05/01/2012 |
1.8 |
0.1627 |
Klebsiella pneumoniae |
Escherichia coli |
X-RAY DIFFRACTION |
3 |
| 4EY2 |
Crystal structure of NDM-1 bound to hydrolyzed methicillin |
Hydrolase/antibiotic |
Metallo-Beta-Lactamase, antibiotic, Hydrolase-antibiotic complex |
05/01/2012 |
1.17 |
0.13 |
Klebsiella pneumoniae |
Escherichia coli |
X-RAY DIFFRACTION |
3 |
| 4FP8 |
Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit |
VIRAL PROTEIN/IMMUNE SYSTEM |
viral fusion protein, immunoglobulin, virus attachment and entry, immune recognition, VIRAL PROTEIN-IMMUNE SYSTEM complex |
06/21/2012 |
2.921 |
0.2122 |
Influenza A virus |
Trichoplusia ni |
X-RAY DIFFRACTION |
1 |
| 3RQJ |
Structure of the neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-((1S,2R)-2-(3-Fluorophenyl)cyclopropylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine |
Oxidoreductase/Inhibitor |
oxidoreductase, enzyme-inhibitor complex, Oxidoreductase-Inhibitor complex |
04/28/2011 |
1.84 |
0.1892 |
Rattus norvegicus |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
| 3RQP |
Structure of the endothelial nitric oxide synthase heme domain in complex with 6-{[(3R,4R)-4-(2-{[(2R/2S)-1-(3-fluorophenyl)propan-2-yl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine |
OXIDOREDUCTASE/INHIBITOR |
oxidoreductase, enzyme-inhibitor complex, OXIDOREDUCTASE-INHIBITOR complex |
04/28/2011 |
2.35 |
0.17788 |
Bos taurus |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
| 3S2Q |
The crystal structure of AT5g51720 (AT-NEET) |
METAL BINDING PROTEIN |
redox, Fe-S cluster, METAL BINDING PROTEIN |
05/17/2011 |
1.75 |
0.181 |
Arabidopsis thaliana |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
| 3SBA |
Zn-mediated Hexamer of T4 Lysozyme R76H/R80H by Synthetic Symmetrization |
HYDROLASE |
metal-mediated synthetic symmetrization, synthetic symmetrization, HYDROLASE |
06/03/2011 |
2.75 |
0.2219 |
Enterobacteria phage T4 |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
| 3SEY |
Zn-mediated Polymer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form II) |
SUGAR BINDING PROTEIN |
metal-mediated synthetic symmetrization, synthetic symmetrization, SUGAR BINDING PROTEIN |
06/11/2011 |
1.85 |
0.2085 |
Escherichia coli |
Escherichia coli |
X-RAY DIFFRACTION |
1 |
| 3SJB |
Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain |
HYDROLASE/TRANSPORT PROTEIN |
Coiled-coil, receptor complex, TA-protein biogenesis, GET pathway, HYDROLASE-TRANSPORT PROTEIN complex |
06/21/2011 |
3.3 |
0.1946 |
Saccharomyces cerevisiae |
Escherichia coli |
X-RAY DIFFRACTION |
1 |